ArticleJournal of the American Heart Association2026
Incident Hypertension in Young Adults With a Mild Estimated Glomerular Filtration Rate Reduction.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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16 authors.
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Abstract
backgroundHypertension is a common, modifiable risk factor for cardiovascular disease with an increasing occurrence in young adults. We examined the association of lower-than-normal kidney function with
methodsWe conducted a historical cohort study of 7.8 million individuals (3.7 million aged 18-39 years) using linked provincial health care data sets from Ontario, Canada, between 2008 and 2021. Cox models were used to examine the association of categorized estimated glomerular filtration rate (eGFR) (60-100 mL/min per 1.73 m
resultsAmong our cohort (mean age, 40.4 years; mean eGFR, 104.9 mL/min), a total of 170 905 (4.6%) individuals developed hypertension among young adults, compared with 279 937 (15.3%) in those aged 40 to 49 years and 588 195 (25.2%) in those aged 50 to 65 years. The adjusted rates of hypertension increased with an eGFR of <100 mL/min, increasing step wise as eGFR declined, and occurred at a higher relative eGFR in young adults compared with older age groups. Among young adults who developed hypertension, cardiovascular events were 6- to 10-fold more common and were more likely with minor eGFR reductions.
conclusionsMinor reductions in eGFR in younger adults are associated with new-onset hypertension and a higher risk of cardiovascular consequences, suggesting early identification, monitoring, and management may be beneficial.
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