ArticleThe Kaohsiung journal of medical sciences2026
Vaccarin Improves Myocardial Ischemia-Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4-Modulated JAK2/STAT3 Pathway Activation.
Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia-reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R-induced dysfunction in vivo and in vitro and examined the associated molecular mechanisms. To explore the protective effects of vaccarin, we established an MI/R injury mouse model and in vitro hypoxia/reoxygenation (H/R) injury model using H9c2 cardiomyocytes. In vivo results showed that vaccarin alleviated MI/R injury. In H9c2 cells, vaccarin partially reversed the H/R-induced elevation of reactive oxygen species and malondialdehyde levels and restored the reduced activity of superoxide dismutase. Vaccarin also suppressed the H/R-induced accumulation of Fe
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