Evidence map›Paper›PMID 42053296›Full record

ArticleJournal of virology2026

The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage.

Rhiannon R Abrahams, Clairine I S Larsen, Raymond Ha, Kinjal Majumder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rhiannon R AbrahamsInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-8988-7976
Clairine I S LarsenInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Raymond HaInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kinjal MajumderInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-1898-8251

Funding

Defining how cellular DNA replication and repair machinery are hijacked by viral pathogensR35GM154938 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Kinjal Majumder · 2024 to 2026
$1.1M
National Institute of Allergy and Infectious Diseases AI148511National Science Foundation DGE-2137424NIGMS NIH HHS GM154938NIGMS NIH HHS R35 GM154938Ruth L. Kirschstein National Research Service Award from NIAID F31AI191692University of Wisconsin ScimedGRS GRSWisconsin Partnership Program G-4942
6 · The paper itself

Abstract

Wild-type adeno-associated virus type 2 (wtAAV2) is a small, non-pathogenic DNA virus within the family

Indexed as

DependovirusDNA DamageKruppel-Like Transcription FactorsPoly (ADP-Ribose) Polymerase-1Binding SitesCell NucleusHEK293 CellsHost-Pathogen InteractionsHumansKruppel-Like Factor 4Protein BindingViral ProteinsKLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription FactorsPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Viral Proteinsadeno-associated viruschromosome conformation captureDNA damagerAAV gene therapy

Identifiers

PMID42053296
PMCPMC13185594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.