ArticleJournal of clinical pharmacology2026
Evaluation of Relative Bioavailability and Food Effect of a Fixed-Dose Combination Tablet of Islatravir and Lenacapavir.
Article in Journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
Long-acting oral HIV-1 treatments can potentially reduce pill burden, treatment fatigue, suboptimal adherence, and treatment failure. A combination of islatravir, a nucleoside reverse transcriptase translocation inhibitor, and lenacapavir, a capsid inhibitor, is being investigated as a weekly oral HIV-1 treatment. In this open-label, phase 1 study of 93 people without HIV, we investigated pharmacokinetics to evaluate the oral relative bioavailability and safety of a fixed-dose combination (FDC) tablet containing islatravir 2 mg and lenacapavir 300 mg, compared with respective single-agent islatravir 2 mg and lenacapavir 300 mg coadministration under fasted conditions, as well as the food effect for FDC administration. Islatravir pharmacokinetics showed similar mean area under the time-concentration curve extrapolated to infinity (AUC
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