ArticleMolecular imaging and biology2026
Estimation and Correction of the Partial Volume Effect Using Personalized Phantoms of Lymph Node Metastases in Lutetium 177 SPECT/CT Dosimetry.
Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aims to quantify and to correct for partial volume effect (PVE) in lymph node metastases of prostate cancer (PC) on Lu-177 SPECT images using 3D-printed phantoms of these structures to establish a ground truth. PROCEDURES: Ten individuals with clearly delineated, SPECT-positive lymph node metastases were retrospectively selected from a cohort of PC patients undergoing radioligand therapy (RLT). Manual segmentation of the metastases was performed on the CT component. The segmented lymph nodes were 3D-printed as patient-specific lymph node phantoms with volumes ranging from 0.18 to 23.7 ml using a high-resolution 3D printer. These phantoms were filled with Lu-177 and analyzed in a SPECT/CT system to quantify PVE. An exponential curve fit of the recovery coefficient (RC) versus the surface-area to volume ratio (SA:V) was derived from the spheres of a NEMA ICE body phantom and used to correct for PVE in the lymph node phantoms. This method was compared with other post-reconstruction partial volume corrections (PVC).
resultsFor a tumor to background ratio (TBR) of 10:1 the RCs varied widely, from 82% to 10.4% depending on phantom size. Using the NEMA IEC body phantom, an exponential correlation was established between SA:V and RC, with R
conclusionsThe low RCs obtained for lymph node metastases suggest that Lu-177-dosimetry is in these structures grossly inaccurate without PVE correction. Applying the SA:V/RC curve established using the NEMA IEC body phantom for this purpose reduces PVE-related errors considerably.
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