Evidence map›Paper›PMID 42053836›Full record

ArticleDiscover oncology2026

Cervical cancer derived extracellular vesicles expressed higher level of CD24 and suppressed the phagocytosis of macrophages.

Fang Shen, Junhao Chen, Yuanyuan Gu, Yao Li, Jingxin Ding, Menglei Zhang, Qing Cong, Guannan Zhou, Keqin Hua

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PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fang Shen *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.
Junhao Chen *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.
Yuanyuan Gu *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.
Yao LiDepartment of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.
Jingxin Ding *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.
Menglei Zhang *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.
Qing Cong *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.
Guannan Zhou *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China. zgnsmmu@163.com.
Keqin Hua *Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical cancer represents one of the most common malignant tumors affecting women worldwide with unsatisfactory therapeutic outcome. CD24 is well acknowledged that could express on cancer cell and block the phagocytosis of macrophages in tumor microenvironment. However, it is unclear whether the cervical cancer derived extracellular vesicles (CC-EVs) block the phagocytosis of macrophages.

methodsCD24 expression was detected in cervical cancer tissues. The CC-EVs were isolated to treat the macrophages. Furthermore, the CD24 expression was detected in CC-EVs. Then we isolated CD24-EVs through transient transfection and CD24

resultsCervical cancer derived EVs could decrease the phagocytosis of macrophages. The CC-EVs expressed high level of CD24, which play the key role in blocking the phagocytosis of macrophages.

conclusionsThe cervical cancer derived EVs express higher level of CD24, which inhibits the phagocytosis of macrophages.

Indexed as

CD24Cervical cancerExtracellular vesicles (EVs)MacrophagesPhagocytosis

Identifiers

PMID42053836
PMCPMC13272704

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.