ReviewDiscover oncology2026
Mechanisms of fatty acid metabolism in tumor metastasis and targeted therapeutic strategies.
Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Fatty acid metabolism is a core metabolic pathway regulating tumor metastasis. Through fatty acid uptake and intracellular transport mediated by CD36 and fatty acid-binding proteins (FABPs), fatty acid oxidation (FAO) regulated by carnitine palmitoyltransferase 1 (CPT1), and fatty acid desaturation modification mediated by stearoyl-CoA desaturase 1 (SCD1) and fatty acid desaturase 2 (FADS2), it modulates the entire process of tumor cell invasion, circulatory survival and distal colonization from the perspectives of membrane lipid remodeling, energy homeostasis and signal transduction. The metabolic heterogeneity of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT)-like cells, as well as the metabolic reprogramming mediated by the target organ microenvironment, further enhance metastatic plasticity and organotropism. Interventional strategies targeting key molecules of fatty acid metabolism have shown promising anti-metastatic potential, providing a core research direction for subsequent precise metabolic targeted therapy against metastasis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.