Evidence map›Paper›PMID 42055208›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2026

Cigarette smoking and long-term incidence of colorectal cancer subclassified by tumor-infiltrating myeloid cells: A prospective cohort study.

Satoko Ugai, Hiroki Mizuno, Kosuke Matsuda, Atsushi Kondo, Yuxue Zhong, Nobuhiro Nakazawa, Satoshi Miyahara, Naoka Murakami, Sara A Väyrynen, Andrew T Chan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Satoko UgaiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Integrative Cancer Research, National Cancer Center Research Institute, Tokyo, Japan; Department of Hygiene and Public Health, Kyorin University School of Medicine, Tokyo, Japan.
Hiroki MizunoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kosuke MatsudaProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Integrative Cancer Research, National Cancer Center Research Institute, Tokyo, Japan.
Atsushi KondoProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Integrative Cancer Research, National Cancer Center Research Institute, Tokyo, Japan.
Yuxue ZhongProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nobuhiro NakazawaProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Integrative Cancer Research, National Cancer Center Research Institute, Tokyo, Japan.
Satoshi MiyaharaProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Naoka MurakamiDivision of Nephrology, Washington University in St. Louis, St. Louis, MO, USA.
Sara A VäyrynenDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Andrew T ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Mingyang SongDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Marios GiannakisDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jeffrey A MeyerhardtDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Juha P VäyrynenProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, And University of Oulu, Oulu, Finland.
Jonathan A NowakProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shuji OginoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Nutrition, Harvard Medical School, Boston, MA, USA; Institute of Science Tokyo, Tokyo, Japan. Electronic address: sogino@bwh.harvard.edu.
Tomotaka UgaiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Integrative Cancer Research, National Cancer Center Research Institute, Tokyo, Japan; Cancer Epidemiology Program, Dana-Farber / Harvard Cancer Center, Boston, MA, USA; Zhu Family Center for Global Cancer Prevention, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: tugai@hsph.harvard.edu.

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FUCHS, CHARLES S · 1991 to 2009
$41.8M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Accelerating Transdisciplinary Epidemiology of Colorectal CancerR35CA197735 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2015 to 2021
$6.0M
The Gut Microbiome, Lifestyle, and Colorectal NeoplasiaU01CA261961 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Mingyang Song · 2022 to 2026
$3.0M
Epigenetic Events and Colorectal Cancer EpidemiologyR01CA151993 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2010 to 2014
$2.6M
Integration of Immunology and Microbiology into Molecular Pathological Epidemiology of Colorectal CancerR50CA274122 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI UGAI, TOMOTAKA · 2023 to 2025
$506k
Integrating diet, lifestyle and tumor tissue molecular subtyping to study the role of adolescent calcium intake on the risk of early onset colorectal neoplasiaR21CA230873 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI OGINO, SHUJI, WU, KANA · 2018 to 2019
$427k
NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA151993NCI NIH HHS R21 CA230873NCI NIH HHS R35 CA197735NCI NIH HHS R50 CA274122NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA261961NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Evidence indicates that cigarette smoking affects anti-tumor immunity. We tested a hypothesis that the association of smoking with long-term colorectal cancer (CRC) incidence might differ by myeloid cell infiltrates in tumors, which may play roles in cancer immune evasion. We utilized the prospective cohort incident-tumor biobank method on two longitudinal prospective cohort studies, namely the Nurses' Health Study and the Health Professionals Follow-up Study. To identify myeloid cells in the tumor microenvironment, we applied multiplexed immunofluorescence (for ARG1, CD14, CD15, CD33, HLA-DR, and KRT) combined with digital image analysis and machine learning. We examined the association of smoking with long-term incidence of CRC subclassified by myeloid cell densities using the multivariable inverse-probability-weighted duplication-method Cox regression model. During the follow-up of 131,143 cohort participants (3,647,434 person-years), we documented 3092 incident CRC cases, including 854 cases with available data on tissue myeloid cells. The association of pack-years smoked with long-term CRC incidence differed by intraepithelial CD14

Indexed as

Cigarette SmokingColorectal NeoplasmsMyeloid CellsAdultAgedFemaleHLA-DR AntigensHumansIncidenceMaleMiddle AgedProspective StudiesHLA-DR AntigensColorectal cancerImmunologyMolecular pathological epidemiologyRisk factorsSmoking

Identifiers

PMID42055208
PMCPMC13241085

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.