Evidence map›Paper›PMID 42056509›Full record

ArticleNature2026

Cytoplasmic competition between separate parental pronuclei in zygotes.

Hirohisa Kyogoku, Mitsusuke Tarama, Masahiro Matsuwaka, Tappei Mishina, Akihito Harada, Reiko Nakagawa, Mami Kumon, Yoshihiro Shimizu, Yasuyuki Ohkawa, Tatsuo Shibata and 2 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hirohisa KyogokuGraduate School of Agricultural Science, Kobe University, Kobe, Japan. hirohisa.kyogoku@panda.kobe-u.ac.jp.ORCID http://orcid.org/0000-0002-0364-3971
Mitsusuke TaramaLaboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID http://orcid.org/0000-0002-2708-1774
Masahiro MatsuwakaLaboratory for Epigenome Inheritance, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0009-0003-3268-6430
Tappei MishinaLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID http://orcid.org/0000-0003-1275-3344
Akihito HaradaDepartment of Multi-Omics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0009-0003-1420-4549
Reiko NakagawaLaboratory for Cell-Free Protein Synthesis, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID http://orcid.org/0000-0002-6178-2945
Mami KumonLaboratory for Epigenome Inheritance, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoshihiro ShimizuLaboratory for Cell-Free Protein Synthesis, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID http://orcid.org/0000-0003-3499-1394
Yasuyuki OhkawaDivision of Transcriptomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-6440-9954
Tatsuo ShibataLaboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan.ORCID http://orcid.org/0000-0002-9294-9998
Azusa InoueLaboratory for Epigenome Inheritance, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-9703-0358
Tomoya S KitajimaLaboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan. tomoya.kitajima@riken.jp.ORCID http://orcid.org/0000-0002-6486-7143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryogenesis begins with a zygote-a single cell with two pronuclei that separately enclose maternal and paternal chromosomes. The functional significance of the separation of parental chromosomes into distinct pronuclei remains unexplored, despite the fact that one-pronuclear biparental zygotes are used clinically

Indexed as

Cell NucleusCytoplasmZygoteAnimalsEmbryonic DevelopmentEpigenesis, GeneticFemaleFertilizationHistonesMethylationMiceHistones

Identifiers

PMID42056509
PMCPMC13233321

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.