Evidence map›Paper›PMID 42056521›Full record

ArticleNature2026

Postprandial lipid metabolism durably enhances T cell immunity.

Alok Kumar, Dayana B Rivadeneira, Isha Mehta, Bingxian Xie, Rachel Cumberland, Supriya K Joshi, Jitendra S Kanshana, William G Gunn, Victoria Dean, Angelina Parise and 10 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Alok KumarDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-4269-3971
Dayana B RivadeneiraDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Isha MehtaDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6009-0787
Bingxian XieDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Rachel CumberlandDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Supriya K JoshiDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Jitendra S KanshanaDivision of Endocrinology and Metabolism, Pittsburgh, PA, USA.
William G GunnDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0007-9070-7550
Victoria DeanDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Angelina PariseDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Kristin MorderDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Erica S MyersHealth Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0000-5711-4912
Steven J MullettHealth Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.
Richard T CattleyDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Stacy L GelhausHealth Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9083-6933
Abigail E Overacre-DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4027-3487
Jishnu DasDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-5747-064X
William F HawseDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Alison B KohanDivision of Endocrinology and Metabolism, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-3127-7283
Greg M DelgoffeDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. gdelgoffe@pitt.edu.ORCID http://orcid.org/0000-0002-2957-8135

Funding

Uncovering the metabolic underpinnings of T cell exhaustionR01AI166598 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2022 to 2025
$3.2M
Metabolic control of regulatory T cell functional identityR01AI171483 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2022 to 2025
$2.4M
Exploring and exploiting metabolic plasticity in regulatory T cellsDP2AI136598 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2017 to 2017
$2.3M
NIAID NIH HHS DP2 AI136598NIAID NIH HHS R01 AI166598NIAID NIH HHS R01 AI171483
6 · The paper itself

Abstract

Although intrinsic metabolic pathways have critical roles in T cell function

Indexed as

Lipid MetabolismPostprandial PeriodT-LymphocytesAnimalsChylomicronsFastingFemaleHumansLymphocyte ActivationMaleMechanistic Target of Rapamycin Complex 1Metabolic ReprogrammingMiceTriglyceridesChylomicronsMechanistic Target of Rapamycin Complex 1Triglycerides

Identifiers

PMID42056521
PMCPMC13293855

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.