ArticlePediatric research2026
Caffeine inhibited the hyperoxia-induced A2AR-ERK/p38 MAPK-IL-8 pathway in type II alveolar epithelial cells to suppress NETs formation in bronchopulmonary dysplasia.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo investigate how caffeine inhibited hyperoxia-induced NET formation and protected against bronchopulmonary dysplasia (BPD).
methodsThe impact of caffeine on NETs secretion in neutrophils triggered by hyperoxia-induced A549 cells was examined. The role of the IL-8/CXCR2 axis in inducing NETs was evaluated using IL-8 and anti-CXCR2 antibody. The impact of caffeine on ERK/p38 MAPK signaling induced by hyperoxia was explored. Finally, a BPD animal model was established to observe the effect of caffeine on hyperoxia-induced lung injury.
resultsCaffeine reduced hyperoxia's inhibitory effect on A549 cell activity and apoptosis, and suppressed the increased secretion of NETs by hyperoxia-induced A549 cells. The IL-8/CXCR2 axis was found to enhance NETs secretion to injury A549 cell. Caffeine inhibited IL-8 secretion in hyperoxia-induced A549 cells, suppressing NETs formation. It also inhibited the A2AR-ERK/p38 MAPK pathway to reduce IL-8 secretion. In the BPD animal model, caffeine alleviated hyperoxia-induced lung injury, lowered inflammatory factors and levels of ERK/p38 MAPK phosphorylation, NETs. However, CGS21680 and IL-8 treatment lessened caffeine's effects.
conclusionCaffeine inhibited A2AR-ERK/p38 MAPK-IL-8 pathway to suppress the formation of NETs for alleviating hyperoxia-induced A549 cell injury. This provides a theoretical basis for developing therapeutic strategies targeting NETs to improve the prognosis of premature infants. IMPACT: Caffeine inhibited hyperoxia-induced NETs formation and exerts a protective effect on bronchopulmonary dysplasia (BPD). Caffeine reduces hyperoxia-induced A549 cell injury and NETs secretion by inhibiting the A2AR-ERK/p38 MAPK-IL-8 pathway. This research offers a new theoretical foundation for comprehending how caffeine improves neonatal BPD. These findings provide a theoretical basis for developing therapeutic strategies targeting NETs. This research offers new insights for improving the prognosis of premature infants with BPD.
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42056536What Socratic holds
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