ArticlePediatric research2026
Early life factors, blood pressure percentile trajectories, and elevated blood pressure in children.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundElevated blood pressure (BP) in childhood is a predictor of adult hypertension.
methodsWe characterized existing blood pressure (BP) percentile trajectories in children aged 3-9 years and examined factors associated with BP trajectory and elevated BP among 1040 participants in a prospective birth cohort study in Durham, North Carolina (2005-2011). We obtained BP measurements from medical records and demographic, social, and behavioral characteristics from questionnaires. We identified systolic blood pressure (SBP) percentile trajectories using group-based trajectory modeling as well as diastolic blood pressure (DBP) percentiles as a secondary outcome. We then calculated associations between trajectory group and covariates of interest using multinomial logistic regression. We also estimated the association of these covariates with elevated BP using generalized estimating equations.
resultsWe identified four distinct SBP percentile trajectories (lower stable, lower increasing, higher stable, and higher decreasing) and three distinct DBP percentile trajectories (lower increasing, higher decreasing, and higher stable). Birthing parent race and ethnicity, pre-pregnancy BMI, relationship status, educational attainment, and gestational diabetes status were significantly associated with offspring SBP percentile trajectory group assignment. Offspring sex assigned at birth, birthing parent race and ethnicity, pre-pregnancy BMI, smoking, relationship status, educational attainment, and chronic hypertension status were significantly associated with offspring DBP percentile trajectory group assignment. Infant sex, preterm birth, birthing parent race and ethnicity, pre-pregnancy BMI, and chronic hypertension status were significantly associated with offspring elevated BP.
conclusionOur results enhance understanding of pediatric SBP and DBP patterns and assist in identifying factors that contribute to elevated BP in children. IMPACT: Our research contributes to understanding of pediatric BP patterns leveraging percentiles which account for age, sex, and height. We identified four distinct SBP and three distinct DBP trajectories in children aged 3-9 years. We identified associations of several social, demographic, and clinical characteristics with childhood BP trajectories and elevated BP. Elevated blood pressure in childhood is a leading precursor for adverse cardiovascular outcomes in adults. Our research may assist in targeted interventions for high-risk groups.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.