ArticleBrain structure & function2026
Functional Breakdown of Temporoparietal Junction Interaction in High-depression Individuals: Evidence from Multi-Metric Connectomics.
Article in Brain structure & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Depression involves impaired cognitive, affective, and social functions associated with aberrant brain network interactions. The temporoparietal junction (TPJ), a multisensory integration hub, exhibits depression-related connectivity alterations, yet the roles of its subregions during subclinical stages remain unclear. This study examined TPJ subregional communication in non-clinical high-depression individuals. Resting-state fMRI data from 586 medication-free young adults were analyzed. Participants were divided into high-depression (HD, N = 130) and low-depression (LD, N = 130) groups using Beck Depression Inventory scores. TPJ was parcellated into anterior (aTPJ), posterior (pTPJ), and ventral (vTPJ) subregions via community detection. Multi-metric connectivity (functional connectivity/FC, total interdependence/TI, Granger causality/GC) seeded from TPJ subregions was compared between groups. Support vector machine (SVM) fusion analysis identified high-contribution features for network alteration modeling. TPJ subregions showed depression-related connectivity patterns: (1) Altered default mode network DMN interactions featuring enhanced anterior DMN (medial prefrontal cortex) connectivity and weakened posterior DMN (posterior cingulate/precuneus) connectivity; (2) Disrupted left TPJ-reward pathway communication (ventral striatum, putamen, amygdala); (3) Right TPJ/left vTPJ hyperconnectivity with cognitive control systems (frontoparietal network, orbitofrontal cortex, anterior cingulate cortex); (4) Enhanced somatosensory-motor connectivity with reduced visual/auditory input; (5) Impaired intra-TPJ communication. TPJ subregions exhibit distinct dysconnectivity patterns in non-clinical depression, affecting self-referential processing, reward integration, and cognitive control. Multi-metric profiling identifies TPJ as a potential pathophysiological biomarker.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.