Trial reportBMC neurology2026
Association between neutrophil percentage-to-albumin ratio and vascular cognitive impairment in patients with cerebrovascular disease: a cross-sectional study.
Trial report in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04999813 (Study on Early Brain Injury Mechanism and Comprehensive Intervention of Vascular Cognitive Impairment), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on Early Brain Injury Mechanism and Comprehensive Intervention of Vascular Cognitive Impairment
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVascular cognitive impairment (VCI) is a common cognitive disorder in patients with cerebrovascular disease. The neutrophil percentage-to-albumin ratio (NPAR), a composite marker reflecting inflammatory and nutrition-related status, has attracted increasing attention, but its association with VCI remains unclear.
methodsThis cross-sectional study included 227 patients with ischemic cerebrovascular disease, including 130 patients with VCI and 97 cognitively normal controls. Logistic regression analyses were performed to examine the association between NPAR and VCI. Quartile-based, standardized, sensitivity, restricted cubic spline, and discrimination analyses were further conducted.
resultsNPAR levels were higher in the VCI group than in controls. In the fully adjusted model, higher NPAR was associated with the presence of VCI (OR = 4.25, 95% CI: 1.45 ~ 12.45, P = 0.008). Quartile-based and per-1-standard-deviation analyses showed generally consistent findings. Restricted cubic spline analysis suggested an approximately linear association within the observed range. NPAR alone showed moderate discrimination for VCI, whereas its incremental value beyond conventional clinical variables was limited.
conclusionsIn this cross-sectional study of patients with ischemic cerebrovascular disease, higher NPAR was associated with the presence of VCI. NPAR may provide supplementary information for the evaluation of VCI status; however, these findings should be interpreted cautiously and require confirmation in larger prospective studies.
trial registrationClinicalTrials.gov, NCT04999813. Registered 10 August 2021.
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