ArticleLipids in health and disease2026
Dietary fiber intake and mortality among adults with hyperlipidemia : a retrospective cohort analysis from NHANES 1999-2018.
Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccording to the reports of previous studies, dietary fiber has a beneficial effect on controlling serum lipid indices. However, it still remains unclear whether dietary fiber has an influence on mortality among individuals with hyperlipidemia.
methodsOur cohort study assessed the association between the daily intake of dietary fiber and both all-cause mortality and cardiovascular disease mortality among adults with hyperlipidemia on the basis of the data of the National Health and Nutrition Examination (1999-2018) participants over 18 years old. For both of the continuous dietary fiber variable and the categorical dietary fiber variable, the Weighted Cox proportional hazards regression models as well as the restricted cubic splines were used to assess this association after categorizing the participants into three groups based on the tertile of the daily intake of dietary fiber.
resultsFor every 10 g/day increase in the daily intake of dietary fiber, after multivariable adjustments, the hazard ratio for all-cause mortality was 0.791 (95% confidence interval 0.704-0.890), while the hazard ratio for cardiovascular disease mortality was 0.768 (95% confidence interval 0.609-0.968). Moreover, compared with participants with daily intake of dietary fiber below 11.4 g, the hazard ratios for participants with daily intake of dietary fiber above 18.15 g were 0.694 (95% confidence interval 0.560-0.860) for all-cause mortality and 0.607 (95% confidence interval 0.399-0.924) for cardiovascular disease mortality. Additionally, the association between the intake of dietary fiber and all-cause mortality remained consistent among most subgroups of adults with hyperlipidemia, such as the subgroup consisting of participants with a TC level ≥ 200 mg/dL, the subgroup composed of participants with a TG level ≥ 150 mg/dL, the subgroup made up of participants with a LDL-C level ≥ 130 mg/dL as well as the subgroup formed by females with a HDL-C level ≤ 50 mg/dL and males with a HDL-C level ≤ 40 mg/dL.
conclusionsFor adults with hyperlipidemia, high daily intake of dietary fiber could reduce the risk of both of all-cause mortality and cardiovascular disease mortality.
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