Evidence map›Paper›PMID 42057136›Full record

ReviewCell communication and signaling : CCS2026

Tissue-derived small extracellular vesicles in cancer diagnosis and prognosis: current insights and future directions.

Benjie Li, Qi Wang, Baokun Fan, Bairen Pang, Yong Li, Junhui Jiang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjie Li *Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China.
Qi Wang *St George and Sutherland Clinical Campuses, School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia.
Baokun FanHealth Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China.
Bairen PangTranslational Research Laboratory of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, China. bairen.pang@unswalumni.com.
Yong LiSt George and Sutherland Clinical Campuses, School of Clinical Medicine, UNSW Sydney, Kensington, NSW, 2052, Australia. y.li@unsw.edu.au.
Junhui JiangTranslational Research Laboratory of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, China. fyyjiangjunhui@nbu.edu.cn.

Funding

Ningbo Major Special Projects No.2023Z162Ningbo Science Foundation No.202002N3193Ningbo Top Medical and Health Research Program No.2022020203
6 · The paper itself

Abstract

backgroundCancer remains one of the leading causes of human death worldwide. Small extracellular vesicles (sEVs) are nanoscale particles that play important roles in intercellular communication in cancer and represent a valuable source for cancer biomarker discovery. Tissue-derived small extracellular vesicles (Ti-sEVs) are a specific subtype of sEVs and have attracted increasing attention as an emerging research area in cancer diagnostics and therapeutics. Recent progress has highlighted the distinct advantages of Ti-sEVs, including greater cancer specificity, minimal exogenous contamination, enhanced potential for cancer biomarker discovery and understanding tumour microenvironment (TME) dynamics.

methodsThis review summarises recent advancements in the preparation, isolation, and characterization of Ti-sEVs. It further discusses current knowledge of their biological functions within the TME and critically evaluates their emerging application in cancer diagnosis and prognosis.

conclusionTi-sEVs offer unique opportunities for cancer biomarker discovery and translational research. However, key challenges remain, including tissue processing variability, methodological standardization, and technical barriers to clinical implementation. Addressing these issues will be essential to realize the full potential of Ti-sEV-based diagnostics and therapeutics and to guide future research in this rapidly evolving field.

Indexed as

Extracellular VesiclesNeoplasmsAnimalsBiomarkers, TumorHumansPrognosisTumor MicroenvironmentBiomarkers, TumorCancer diagnosisCancer prognosisExtracellular vesiclesTissue-derived small extracellular vesiclesTumour microenvironment

Identifiers

PMID42057136
PMCPMC13274013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.