ArticleiScience2026
AMPK-p38 axis converts human pluripotent stem cells to naive state.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotent stem cells (PSCs) exist in either a "primed" state or a "naive" state. While several protocols are available to convert primed human PSCs (hPSCs) to the naive-state hPSCs, they often require multiple exogenous factors. Here, we show that the activation of AMP-activated protein kinase (AMPK) or its downstream p38 alone induces naive conversion. Primed hPSCs cultured with activated AMPK-p38 displayed key naive features, including naive marker expression, three-germ-layer differentiation, epigenomic resetting, and increased mitochondrial activity. An AMPK activator-5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR)-synergistically enhances the naive conversion efficiency of reported conversion protocols. Single-cell RNA sequencing (scRNA-seq) with RNA velocity analyses and Totem trajectory mapping identified an intermediate state bridging the primed and naive states. These cells showed three upregulated gene groups: (1) pluripotency genes (e.g.,
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.