ArticleRegenerative therapy2026
Lpar3-mediated macrophage polarization promotes inflammatory tooth extraction socket healing and alveolar bone regeneration.
Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Delayed healing of extraction sockets under inflammatory conditions, such as periodontitis, remains a common clinical challenge. Persistent inflammation and dysregulated immune responses are increasingly recognized as key factors impairing alveolar bone regeneration; however, the underlying immunoregulatory mechanisms remain incompletely understood. Methods: An inflammatory tooth extraction model was established in mice. Macrophage polarization in healing sockets was analyzed by immunofluorescence and flow cytometry, and LPAR3/Lpar3 expression was examined in mouse extraction socket tissues and human alveolar bone debris collected from healing sites using qRT-PCR. Results: M2 macrophage polarization was significantly impaired in inflammatory tooth extraction sockets, accompanied by marked downregulation of LPAR3/Lpar3 expression. Conclusion: These findings demonstrate that Lpar3-mediated macrophage polarization plays a critical role in inflammatory tooth extraction socket healing. Targeting the LPA-Lpar3 axis may represent a promising immunoregulatory strategy to enhance alveolar bone regeneration following tooth extraction under inflammatory conditions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.