Evidence map›Paper›PMID 42059554›Full record

ArticleMicrobiology spectrum2026

Paclitaxel-induced tubulin dysfunction stalls parasite development: synergistic potential with artemisinin against resistant strains.

Yongxin Tang, Xinyu Zhang, Xiaohui He, Tao Jiang, Jun Cao, Xinyu Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yongxin Tang *Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID 0009-0003-2252-2539
Xinyu Zhang *Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Xiaohui He *National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China.
Tao JiangState Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-1427-4793
Jun CaoCenter for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID 0000-0001-5298-9234
Xinyu YuNational Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, China.ORCID 0000-0002-1339-3558

Funding

National Natural Science Foundation of China 82102424National Natural Science Foundation of China 82320108014
6 · The paper itself

Abstract

In this study, paclitaxel (PTX), a well-characterized microtubule-stabilizing agent, was systematically investigated for its antimalarial potential against drug-resistant

Indexed as

AntimalarialsArtemisininsPaclitaxelPlasmodium falciparumTubulinAnimalsDrug ResistanceDrug SynergismHumansInhibitory Concentration 50Malaria, FalciparumAntimalarialsartemisininArtemisininsPaclitaxelTubulinartemisinin resistancecombination therapypaclitaxelPlasmodiumsynergistic effect

Identifiers

PMID42059554
PMCPMC13227983

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.