ReviewMolecular biology reports2026
Insulin resistance, inflammation, oxidative stress and dysregulated WNT/β-Catenin signaling in polycystic ovary syndrome: A review.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic ovary syndrome (PCOS) is a multifaceted reproductive and endocrine health issue affecting reproductive aged women, characterized by insulin resistance (IR), chronic low-grade inflammation (LGI), oxidative stress (OS) and dysregulated WNT/β-catenin signaling pathway. Although a part of the involved mechanism in PCOS occurrence is discovered, the exact etiology involving intricate relationships between OS, inflammatory markers and dysregulated WNT/β-catenin signaling pathway in PCOS are still unknown. This review aimed to explore the interplay between IR, LGI, OS and dysregulated WNT/β-catenin signaling pathway in the pathophysiology of PCOS. A comprehensive literature search was conducted to identify relevant studies investigating the role of OS, inflammatory markers and WNT/β-catenin signaling in PCOS. Databases including PubMed, Scopus, Web of Science and Google Scholar were searched using keywords as, "PCOS and oxidative stress", "Insulin Resistance and PCOS", "Inflammation and PCOS", "WNT/β-catenin signaling in PCOS". The search was limited to studies published in English up to 2025 without any restrictions on publication year. In conclusion, PCOS is a complex and multifactorial disorder driven by the intricate involvement of insulin resistance, chronic low-grade inflammation, oxidative stress and dysregulated WNT/β-catenin signaling pathway among reproductive age women. Although substantial progress has been made in elucidating these interconnected mechanisms, the etiological pathways remain incompletely understood. The evidences collected in this study highlights that these physiological and signaling factors do not act in isolation but collectively contribute to the initiation and progression of various pathological mechanisms of PCOS among young women. A deeper understanding of their physiological and molecular crosstalk is essential for identifying reliable biomarkers and novel therapeutic targets.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.