Evidence map›Paper›PMID 42061237›Full record

ReviewPoultry science2026

The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production.

Xueqing Xiao, Wenrui Zhen, Dongying Bai, Bo Zheng, Yanli Wang, Xiqiang Ma, Xiaolin Xie, Yi Zhang, Fangshen Guo, Koichi Ito and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xueqing XiaoDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.
Wenrui ZhenDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
Dongying BaiDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
Bo ZhengDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.
Yanli WangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China.
Xiqiang MaInnovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang 471023, China.
Xiaolin XieInnovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang 471023, China.
Yi ZhangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
Fangshen GuoDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
Koichi ItoDepartment of Food and Physiological Models, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Ibaraki 319-0206, Japan.
Bingkun ZhangState Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Cai ZhangDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China.
Yanbo MaDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China; Innovative Research Team of Livestock Intelligent Breeding and Equipment, Science & Technology Innovation Center for Completed Set Equipment, Longmen Laboratory, Luoyang 471023, China; Henan International Joint Laboratory of Animal Welfare and Health Breeding, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China. Electronic address: mayanbo_haust@haust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress and inflammation commonly occur in modern poultry farming, where they are closely linked mechanistically during the progression of disease and adaptation to stressors. This review synthesizes current evidence to outline cyclooxygenase-2 (COX-2) and downstream prostaglandin E2 (PGE₂) signaling via EP receptors as a key molecular nexus that connects excessive reactive oxygen species (ROS) with sustained inflammatory damage. In poultry, a range of stressors, such as heat stress, high stocking density, mycotoxin exposure, heavy metals, and pathogen challenges, promote ROS accumulation from sources such as mitochondria and NADPH oxidase (NOX). These disruptions in redox balance trigger regulatory pathways involving MAPK and NF-κB/AP-1, thereby upregulating PTGS2 (the gene for COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1), leading to increased PGE₂ production. In turn, the PGE₂/EP signaling pathway can enhance NOX activity, alter both innate and adaptive immune functions, and exacerbate barrier dysfunction in the intestine, liver, respiratory mucosa, and immune-related organs, establishing a reinforcing loop of ROS, COX-2, and PGE₂. We further discuss how the effects of COX-2 vary by tissue and pathogen, contributing to slowed growth, disrupted immunity, enhanced viral susceptibility, and damage to organs, and discuss potential intervention approaches such as Nrf2-focused antioxidants, nutrients that strengthen barriers, and targeted modulation of COX-2 and mPGES-1 activity and EP receptor signaling to disrupt the link between oxidative load and escalating inflammation. Finally, we outline a framework integrating standardized stress and pathogen challenges with eicosanoid and EP receptor profiling to guide targeted interventions on the COX-2 prostaglandin network in poultry.

Indexed as

Avian ProteinsChickensCyclooxygenase 2InflammationOxidative StressPoultryPoultry DiseasesAnimalsSignal TransductionAvian ProteinsCyclooxygenase 2Cyclooxygenase-2Poultry productionReactive oxygen speciesRedox-inflammation crosstalk

Identifiers

PMID42061237
PMCPMC13141724

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.