ArticleImmunity2026
Metabolic and transcriptional plasticity supports CD8
Abstract read
In one paragraph
Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Neutrophil-based immunotherapy: A metabolic lens on mechanisms and therapeutic implications.Clinical and translational medicine · 2026Review
- Critical illness expands a transcriptionally distinct hypometabolic CD8bioRxiv : the preprint server for biology · 2026Article
- Versatile electroporation protocols enable reproducible CRISPR-RNP delivery across multiple primary mouse cells of the hematopoietic lineage.Frontiers in immunology · 2026Article
- Integrating T cell signaling and metabolism to enhance T cell engager responses in solid tumors.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Michael ScaglioneDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Montana KnightDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Krittin TrihemasavaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kelly RomeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Anne-Sophie ArchambaultDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada.
Juhee OhDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada.
Erin TanakaDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada.
Elise HallDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tran Ngoc Van LeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Caleb L LinesDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Brian GoldspielDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hossein FazeliniaDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Clemence QueriaultDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lucien TurnerDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tanay ParnaikDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Jimmy XuDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Morgan BrownDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Oishi BardhanDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jessie AxsomDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Frederick C BennettDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Lynn A SpruceProteomics Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Caroline BartmanDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Clementina MesarosDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Ramon I Klein GeltinkDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada; University of British Columbia, Edwin S.H. Leong Centre for Healthy Aging, Vancouver, BC, Canada; BC Cancer Research Centre, Department of Molecular Oncology, Vancouver, BC, Canada.
Crystal S ConnDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Will BailisDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: bailisw@chop.edu.
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MStress-modified growth signaling in dynamic nutrient environmentsR35GM138085 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Will H. Bailis · 2020 to 2026
$2.7MDynamics of RNA regulation and noncanonical translation between cell statesR35GM154896 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Crystal S Conn · 2024 to 2026
$1.2MElucidating the Regulation and Requirement of the NAD salvage pathway in CD8+ T Cell ExhaustionF31CA261156 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TURNER, LUCIEN · 2021 to 2023
$136kNCI NIH HHS F31 CA261156NCI NIH HHS P30 CA016520NCI NIH HHS T32 CA009140NIGMS NIH HHS R35 GM138085NIGMS NIH HHS R35 GM154896
Abstract
CD8
Indexed as
CD8-Positive T-LymphocytesNeoplasmsStress, PhysiologicalActivating Transcription Factor 4AnimalsMetabolic ReprogrammingMiceMice, Inbred C57BLMitochondriaNutrientsTranscription, GeneticTumor MicroenvironmentActivating Transcription Factor 4Atf4 protein, mouseamino acidsanti-tumor immunityATF4CD8(+) T cellsCEBPGGCN2HRIimmunometabolismintegrated stress responsemTORnutrient stresspolysome profilingstress adaptationT cell exhaustionT cellstranslationtumor-infiltrating lymphocyte
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.