Macrophage-Mediated

Estela Pérez, Marta Navarro, Alfonso Ibarra, Ignacio de Blas, Marta Pérez, Lluís Luján, Víctor Sebastián

Abstract read

In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Estela PérezDepartment of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain.ORCID 0000-0003-0844-6026

Marta NavarroInstitute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza, Mariano Esquillor Gómez Street I+D+i building, Zaragoza 50018, Spain.

Alfonso IbarraInstitute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza, Mariano Esquillor Gómez Street I+D+i building, Zaragoza 50018, Spain.

Ignacio de BlasAgri-Food Institute of Aragon (IA2), University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain.ORCID 0000-0002-1204-4356

Marta PérezAgri-Food Institute of Aragon (IA2), University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain.

Lluís LujánDepartment of Animal Pathology, University of Zaragoza, 177 Miguel Servet Street, Zaragoza 50013, Spain.ORCID 0000-0002-2053-9842

Víctor SebastiánInstitute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza, Mariano Esquillor Gómez Street I+D+i building, Zaragoza 50018, Spain.ORCID 0000-0002-6873-5244

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aluminum (Al) in the form of γ-aluminum oxyhydroxide (γ-AlOOH) nanoparticles has been used as a vaccine adjuvant for nearly a century. At injection sites, animals and humans develop granulomatous inflammation, in which macrophages may contain intracellular crystalline-like structures, so-called crystalloid bodies (CBs), morphologically distinct from the injected adjuvant. This raised the hypothesis that CBs may originate from the

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineAluminum HydroxideAluminum OxideGranulomaMacrophagesAnimalsCrystallizationNanoparticlesSheepAdjuvants, ImmunologicAdjuvants, VaccineAluminum HydroxideAluminum Oxidealuminum oxide hydroxidecrystalloid bodiesgamma-aluminagranulomasintracellular crystallizationmacrophagessheepvaccine adjuvants

Identifiers

PMID42062044

DOI10.1021/acsami.6c04089

PMCPMC13181710

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.