Evidence map›Paper›PMID 42062238›Full record

Trial reportActa obstetricia et gynecologica Scandinavica2026

Laparoscopically guided transversus abdominis plane block versus local wound infiltration analgesia in laparoscopic surgery for peritoneal endometriosis: A prospective randomized controlled double-blinded LTAP-trial.

Anna M Terho, Terhi Puhto, Johanna Laru, Outi Uimari, Pasi Ohtonen, Tero Rautio, Sari Koivurova

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04735770 (Laparoscopically Inserted Transversus Abdominis Plane Block Versus Wound Local Anesthesia in Laparoscopic Endometriosis Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04735770 nacompletednot on this map

Laparoscopically Inserted Transversus Abdominis Plane Block Versus Wound Local Anesthesia in Laparoscopic Endometriosis Surgery: a Prospective Randomized Controlled Double-blinded LTAP-trial

TypeinterventionalSponsorOulu University HospitalRan2021 to 2023Enrolled46ConditionsEndometriosis, Peritoneum, Postoperative PainArmsPostoperative pain management: LTAP block or local wound anesthesia with levobupivacaine
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna M TerhoDepartment of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0003-3957-3466
Terhi PuhtoDepartment of Anesthesiology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Johanna LaruDepartment of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Outi UimariResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.
Pasi OhtonenResearch Service Unit, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Translational Medicine Research Unit, University of Oulu, Oulu, Finland.ORCID 0000-0001-8245-3000
Tero RautioDepartment of Surgery, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Medical Research Center, University of Oulu, Oulu, Finland.
Sari KoivurovaDepartment of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.

Funding

Finnish state research grantSuomen Kulttuurirahasto
6 · The paper itself

Abstract

introductionEndometriosis patients often suffer from more severe pain in association with surgical procedures. The aim of this study was to investigate whether laparoscopically guided transversus abdominis plane block (LTAP) offers an opioid-sparing effect compared to local wound infiltration (LWI) analgesia in laparoscopic surgery performed for suspected peritoneal endometriosis. MATERIAL AND

methodsIn this single-center prospective, randomized, controlled, double-blinded clinical study, 46 patients were randomized to receive either levobupivacaine inserted in the four quadrants of the abdomen at LTAP points and saline at trocar sites (n = 23) or saline at the LTAP points and levobupivacaine at trocar sites (n = 23). The study size was based on a power calculation. The primary outcome, opioid consumption 24 h postoperatively, was measured using patient-controlled analgesia pumps. Secondary outcomes included postoperative pain scores and other enhanced recovery after surgery (ERAS) measures, as well as patient outcome questionnaires at six months after surgery. Statistical analyses were performed on an intention-to-treat basis. The study was prospectively registered in Clinicaltrials.gov, ID: NCT04735770, Jan 19, 2021; https://clinicaltrials.gov/study/NCT04735770?term=LTAP&rank=2.

resultsThere was no significant difference in the mean opioid consumption (iv morphine equivalents) between the study groups: 31.8 ± 25.5 mg in the LTAP group and 27.5 ± 19.3 mg in the LWI group (mean difference 4.3 mg, 95% CI -9.2 to 17.7, p = 0.52). No significant differences were found in the postoperative pains scores, mean operation times, mean total blood loss, or mobilization between the study groups. 17 (73.9%) patients in each group received histological diagnosis of peritoneal endometriosis of the samples obtained during surgery. Times to discharge were 24.4 ± 4.3 (LTAP) and 28.1 ± 14.8 h (LWI), p = 0.25. No complications related to LTAP or LWI were reported.

conclusionsIn this study performed on women suffering from long-term abdominal pain preoperatively, no significant differences were found between LTAP and LWI as regards to postoperative opioid consumption, postoperative pain, ERAS factors, or safety.

Indexed as

Anesthetics, LocalEndometriosisLaparoscopyNerve BlockPeritoneal DiseasesPostoperative PainAbdominal MusclesAdultAnalgesics, OpioidDouble-Blind MethodFemaleHumansLevobupivacainePain MeasurementProspective StudiesAnalgesics, OpioidAnesthetics, LocalLevobupivacaineendometriosis surgeryERASlaparoscopylocal wound infiltrationLTAPtransversus abdominis plane block

Identifiers

PMID42062238
PMCPMC13191811

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.