ArticleFrontiers in pediatrics2026
The role of systemic immune-inflammation Index in predicting the diagnosis of severe pneumonia in children.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to evaluate the role of Systemic Immune-Inflammation Index (SII) in predicting the diagnosis of severe pneumonia in children. Methods: A retrospective analysis included 595 pediatric community-acquired pneumonia (CAP) patients from the Affiliated Hospital of North Sichuan Medical College (January 2024-July 2025). Patients were randomly divided into development (70%) and validation (30%) sets. General clinical data and SII were collected. Statistical analysis included Mann-Whitney U, chi-square, multivariate logistic regression, and ROC analysis. A predictive nomogram was developed and evaluated for calibration, discrimination, and clinical utility. Results: SII was an independent risk factor for severe pneumonia. An SII ≥738.0 significantly increased severe pneumonia risk. A combined model including SII, infection status, length of hospital stay, and ICU admission showed higher predictive accuracy than SII alone. Conclusion: SII is a useful biomarker for predicting severe pneumonia in children. The nomogram integrating SII with clinical factors demonstrates good predictive performance.
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