ArticleOphthalmology science2026
Genome-Wide Meta-Analysis for High Myopia Provides Insights into Disease Mechanisms and Reveals a Causal Link to Primary Open-Angle Glaucoma.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Hypoxia-induced OPN5 expression is associated with matrix-preserving responses in human scleral fibroblasts.Frontiers in neuroscience · 2026Article
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Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the genetic architecture of high myopia. Design: A meta-analysis of genome-wide association studies (meta-GWASs). Participants: A total of 7867 individuals with high myopic eyes and 21 700 controls were enrolled. Methods: We performed a meta-GWAS comprising 3910 cases with high myopic eyes and 5718 controls in the discovery stage. A replication study included an independent set of 3957 participants with high myopic eyes and 15 982 control participants. Functional enrichment analysis was conducted using FUMA and ToppFun. We assessed shared genetic architectures between high myopia and 4 phenotypes (2 ocular diseases and 2 biometric features) using the LDSC software, followed by the evaluation of causality utilizing a bidirectional inverse variance-weighted Mendelian randomization (IVW-MR) analysis with sensitivity analyses. Main Outcome Measures: The association between single-nucleotide polymorphisms and high myopia. Results: We identified 10 loci exceeding genome-wide significance ( Conclusions: Our study identified 2 novel high myopia-associated loci. Subsequent functional enrichment analysis offered important insights into the molecular biology of high myopia, demonstrating potential therapeutic targets. Previous studies could not definitively determine whether high myopia had a causal effect on POAG due to the potential influence of unmeasured confounders. By utilizing an MR method, which can control for even unmeasured confounders, this study provides data that support a causal association of high myopia on POAG. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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