ReviewFrontiers in immunology2026
Decoding the dual roles of monocytes in tumor immunity: from immunosurveillance to immune evasion.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocytes are innate immune cells of the mononuclear phagocyte system, extensively involved in immune and inflammatory responses, and play a critical regulatory role in tumor development and progression. Different monocyte subsets can exert either pro-tumor or anti-tumor functions by modulating immune responses. Through the secretion of cytokines and chemokines, monocytes regulate immune activity, while tumor cells utilize these signaling pathways to influence monocyte polarization, inducing their transformation into immunosuppressive phenotypes. The origin, migration, polarization, and transformation of monocytes within the tumor microenvironment represent key research areas in current cancer immunotherapy. Precise regulation of monocyte function holds promise for developing novel strategies in tumor immunotherapy. Current approaches, such as monocyte-mediated vaccines and combination therapies with immune checkpoint inhibitors, have emerged as major research focuses in cancer immunotherapy. This review summarizes the mechanisms by which monocytes regulate antitumor immune responses and discusses recent advances in their therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.