ArticleFrontiers in immunology2026
Protective role of mucosa-associated invariant T cells in sepsis-related liver injury.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and objective: Sepsis is a life-threatening condition characterized by increasing global incidence, fundamentally driven by immune dysregulation. The liver, crucial for pathogen clearance and inflammatory modulation during sepsis, frequently exhibits functional impairment. Mucosal-associated invariant T (MAIT) cells bridge innate and adaptive immunity and are integral to antimicrobial defense. Their specific role in sepsis-related liver injury (SRLI) remains unclear. This study aims to elucidate MAIT cell alterations and function in SRLI using clinical cohorts and murine models. Methods: The cohort comprised 47 SRLI patients, 37 with non-septic acute liver injury (NSLI), 34 patients with non-associated liver injury in sepsis (NLIS), and 115 healthy controls (HC). Peripheral blood MAIT cells were characterized by flow cytometry for frequency, phenotype, and cytokine production. Results: In the SRLI group, the proportion of peripheral blood MAIT cells was significantly decreased compared to the HC group. Regarding activation (CD69 Conclusion: In the context of SRLI, peripheral blood MAIT cells exhibit a diminished frequency, functional impairment, and a phenotypic shift toward a Th17-like profile. Among these, bilirubin plays a key role. Ultimately, MAIT cells exert a protective role in sepsis-induced liver injury by suppressing excessive inflammatory responses.
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