Efficacy of an internet-based version of the unified protocol for transdiagnostic treatment of emotional disorders in adolescents (iUP-A): A randomized active-controlled trial.

Background: Emotional disorders are highly prevalent among adolescents and often co-occur, underscoring the need for transdiagnostic interventions. Internet-delivered interventions offer a promising avenue to increase access to evidence-based care for youth. Objective: This study examined the effectiveness of the self-administered internet-delivered version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (iUP-A), applied by means of the platform Method: Adolescents with comorbid anxiety and/or depressive disorders (age range = 13-18 years; 80.3% girls) were randomly allocated to receive the iUP-A ( Results: Participants in the iUP-A condition showed significant improvements from pre- to post-treatment across all self-reported and clinician-rated measures, whereas no such improvements were observed in the control condition. Substantial gains were observed across all outcomes, with large effect sizes maintained or enhanced throughout the follow-up period. Improvements were evident across multiple domains, including internalizing symptoms, anxiety and depressive disorder-symptoms, and overall functioning. Conclusions: The iUP-A appears to be an effective and feasible digital intervention for adolescents with emotional disorders. Findings support its potential for broad implementation in clinical and community settings.