Evidence map›Paper›PMID 42064761›Full record

ReviewFrontiers in endocrinology2026

Integrating behaviour, physiology, and immune response to social stress in fish.

Svante Winberg, Pavla Hubená

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Svante WinbergBehavioral Neuroendocrinology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Pavla HubenáBehavioral Neuroendocrinology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dominance hierarchies in fish are established through conflicts and lead to significant differences in stress physiology, behaviour, and immune function between dominant and subordinate individuals. This review explores the relationship between social stress within these hierarchies, individual variations in stress responses and cognitive bias towards stressful situations, and the impact of conflicts on future performance and interactions between stress and the immune system. Fish express divergent stress coping styles (proactive and reactive) that differ in the reactivity of the stress axes ending with the release of the major stress hormones (adrenaline and cortisol). Social stressors, like conflicts, are perceived differently by proactive and reactive fish, leading to varying levels of stress hormone release. The stress hormones interact with the immune system, changing individuals' ability to fight off pathogens. Pro-inflammatory cytokines highly activated in reactive individuals under stress can provide feedback to the monoaminergic system in the brain, resulting in depression-like, anxiety-like, or "sickness" behaviour. The review also discusses strategies for reducing social stress in fish and enhancing their overall health in aquaculture, while emphasising the importance of considering these factors in research settings to prevent data bias.

Indexed as

Behavior, AnimalFishesStress, PsychologicalAdaptation, PsychologicalAnimalsCoping Skillsaggressioncopingimmune responseproactivereactivestresstranscriptomics

Identifiers

PMID42064761
PMCPMC13124584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.