Evidence map›Paper›PMID 42064914›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Indirect Genetic Effects on Alcohol Use Disorder and Nicotine Dependence.

Mannan Luo, Victória Trindade Pons, Michael Zakharin, Jean-Baptiste Pingault, Nathan A Gillespie, Hanna M van Loo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mannan LuoDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0003-3923-2362
Victória Trindade PonsDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-5779-8285
Michael ZakharinVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-3689-4635
Jean-Baptiste PingaultDepartment of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, United Kingdom.ORCID 0000-0003-2557-4716
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0001-8655-2823
Hanna M van LooDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-9282-8053

Funding

Using transmitted and untransmitted gene networks to identify molecular pathways to substance use & misuse in genetically controlled twinsR01DA052453 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI GILLESPIE, NATHAN ALEXANDER, VLADIMIROV, VLADIMIR IVANOV · 2021 to 2024
$2.2M
NIDA NIH HHS R01 DA052453
6 · The paper itself

Abstract

Substance use disorders run in families, yet the mechanisms underlying intergenerational transmission remain unclear. We investigated indirect genetic effects, pathways through which parental genotypes influence offspring phenotypes via the family environment, for alcohol use disorder (AUD), nicotine dependence (ND), and related quantitative outcomes, and aimed to identify family environmental factors through which such effects may operate. Using transmitted and non-transmitted polygenic scores (PGS) constructed for problematic alcohol use, tobacco use disorder, and general addiction liability, we analyzed 5972 European-ancestry adult offspring with at least one genotyped parent from the population-based Lifelines cohort (Netherlands). Offspring outcomes included lifetime DSM-5 AUD diagnosis, AUD symptom count, maximum drinks in 24 hours, Fagerström Test for Nicotine Dependence score, and cigarettes per day. AUD findings were meta-analyzed with data from the Brisbane Longitudinal Twin Study (

Identifiers

PMID42064914
PMCPMC13127519

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.