ArticleFrontiers in neurology
Longitudinal retinal microvascular changes and their association with white matter hyperintensities in neuromyelitis optica spectrum disorder.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy characterized by recurrent inflammatory attacks within the central nervous system. Beyond optic neuritis, diffuse retinal and cerebral alterations may occur. Optical coherence tomography angiography (OCTA) enables the non-invasive assessment of retinal microvasculature and may provide insight into longitudinal retinal changes and their association with cerebral white matter hyperintensities (WMHs). Methods: In this longitudinal observational study, 45 aquaporin-4 antibody-positive NMOSD patients and 45 age- and sex-matched healthy controls underwent OCTA imaging. Radial peripapillary capillary (RPC) density was measured in the peripapillary region, while superficial vascular complex (SVC), deep vascular complex (DVC), and foveal avascular zone (FAZ) area were assessed in the macular region. Brain MRI was performed at baseline and at a 1-year follow-up, and WMH burden was rated using the Fazekas scale. Associations between OCTA metrics and WMHs were evaluated using regression models adjusted for age and disease duration, and longitudinal changes were analyzed using mixed-effects models. Results: At baseline, NMOSD eyes, including those without prior optic neuritis, showed significantly reduced RPC, SVC, and DVC densities and an enlarged FAZ area compared with controls (all Conclusion: OCTA reveals dynamic retinal microvascular alterations in NMOSD and a consistent association between reduced peripapillary capillary density and WMH burden. These findings are observational and do not imply causality, but they support the use of OCTA as a sensitive tool for monitoring retinal involvement in NMOSD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.