ArticleCell biology and toxicology2026
METTL14 modulates the autophagy-pyroptosis pathway in fibroblasts by modifying BECN1 through m
Article in Cell biology and toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiabetic foot ulcers (DFUs) are prevalent complication in diabetes. METTL14 serves as a key regulator of both autophagy and pyroptosis, both essential for the healing of DFUs. Simiao Yong'an Decoction (SYD) has demonstrated potential in promoting skin wound healing. This study investigates how METTL14 functions as a main regulator in DFU wound healing during SYD treatment and explores the underlying mechanisms.
methodsBoth qPCR and western blot assays were performed to determine METTL14 and BECN1 expression. DFU rat models and fibroblasts stimulated with high glucose (HG) were used to evaluate the role of METTL14 in autophagy, pyroptosis, pro-angiogenic ability, and wound healing through both loss- and gain-of-function assays. The association between METTL14 and BECN1 was examined via MeRIP and RNA stability assays. Futhermore, the therapeutic effects of SYD on DFUs were assessed.
resultsExposure to HG reduced METTL14 levels in fibroblasts, resulting in reduced cell viability and migration, lowered autophagy, and increased pyroptosis. Increasing METTL14 expression reversed these cellular impairments and enhanced angiogenesis driven by fibroblasts. Mechanistically, METTL14 stabilized BECN1 mRNA via m
conclusionsMETTL14-mediated m
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