Evidence map›Paper›PMID 42065817›Full record

ArticleAnnals of biomedical engineering2026

Integrated Strain-Flow Analysis for Early Assessment of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.

Mohammad Saber Hashemi, Ahmad Falahatpisheh, Yasaman Farsiani, Yuri Matusov, Siddharth Singh, Kambiz Ghafourian, Gianni Pedrizzetti, Arash Kheradvar

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In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Saber HashemiDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Ahmad FalahatpishehDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Yasaman FarsianiDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Yuri MatusovDivision of Pulmonary & Critical Care Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Siddharth SinghCedars Sinai Medical Center, Los Angeles, CA, USA.
Kambiz GhafourianCedars Sinai Medical Center, Los Angeles, CA, USA.
Gianni PedrizzettiDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Arash KheradvarDepartment of Biomedical Engineering, University of California, Irvine, CA, USA. arashkh@uci.edu.ORCID http://orcid.org/0000-0003-3864-1359

Funding

Volumetric Echocardiographic Particle Image Velocimetry for Grading the Severity of Mitral Valve RegurgitationR01HL153724 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arash Kheradvar · 2022 to 2026
$3.9M
Computational and Experimental Modeling of Subclinical Leaflet Thrombosis in Bioprosthetic Aortic ValvesR01HL157631 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FOGELSON, AARON L, GRIFFITH, BOYCE EUGENE · 2022 to 2025
$2.7M
Reciprocal effects between scaffold geometry and ventricular vortex flow on viability and performance of tissue-engineered mitral valveR01HL162687 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arash Kheradvar · 2023 to 2026
$2.3M
High-speed 4D echocardiography system with adjustable multi-planar acquisitionR56HL173809 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KHERADVAR, ARASH, YEN, JESSE T-P · 2024 to 2024
$678k
Directorate for Engineering 2109959NHLBI NIH HHS HL153724NHLBI NIH HHS HL157631NHLBI NIH HHS HL162687NHLBI NIH HHS HL173809NHLBI NIH HHS R01 HL153724NHLBI NIH HHS R01 HL157631NHLBI NIH HHS R01 HL162687NHLBI NIH HHS R56 HL173809
6 · The paper itself

Abstract

purposeEarly detection of right ventricular (RV) dysfunction is essential in pulmonary arterial hypertension (PAH) but remains challenging using conventional echocardiography. This study investigates the feasibility of a noninvasive, physics-based framework using three-dimensional (3D) echocardiography that integrates myocardial strain and volumetric flow analysis to characterize RV mechanical performance across stages of PAH.

methodsA prospective pilot study (N = 15) enrolled healthy controls, PAH patients with preserved RV size, and PAH patients with RV dysfunction. Deformation was evaluated by principal strain analysis and by conventional (longitudinal, circumferential) components. Hemodynamic metrics included hemodynamic forces and energetic properties that were derived using a physics-informed volumetric echocardiographic particle image velocimetry (V-Echo-PIV) method applied to contrast-enhanced acquisitions.

resultsDeformation analysis revealed that longitudinal strain was significantly reduced even in PAH patients with preserved RV dimensions, while second principal (secondary) strain showed a distinctive sign reversal, indicating a paradoxical systolic lengthening, early in the disease. The analysis of hemodynamic forces showed a marked reduction in systolic propulsion across all PAH stages. In contrast, energetic abnormalities were predominantly observed at later stage of the disease.

conclusionsThe integration of 3D myocardial strain with fluid dynamics provides a comprehensive physiological assessment of RV remodeling. While strain and systolic propulsion appear as sensitive markers for early dysfunction, diastolic energetics may support disease staging. This noninvasive framework shows promise for early detection and longitudinal monitoring of PAH patients.

Indexed as

3D echocardiographyPulmonary arterial hypertensionRight ventricular functionVolumetric echocardiographic particle image velocimetry

Identifiers

PMID42065817
PMCPMC13492204

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.