Evidence map›Paper›PMID 42067735›Full record

ArticleMolecular imaging and biology2026

Dual Quantification of Skeletal Muscle Perfusion and Metabolism in a Porcine Model of Peripheral Artery Disease Using Multiparametric

Ting-Heng Chou, Mahboubeh Nabavinia, Eleanor T Rimmerman, Corrin Mansfield, Kumudha Narayana Musini, Nguyen K Tram, Mitchel R Stacy

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In one paragraph

Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ting-Heng ChouCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA.
Mahboubeh NabaviniaCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA.
Eleanor T RimmermanCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA.
Corrin MansfieldCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA.
Kumudha Narayana MusiniCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA.
Nguyen K TramCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA.
Mitchel R StacyCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, WB413343215, USA. mitchel.stacy@nationwidechildrens.org.ORCID http://orcid.org/0000-0002-8423-1011

Funding

Radiotracer-Based Imaging for Quantitative Assessment of Skeletal Muscle Perfusion in Peripheral Artery DiseaseR01HL135103 · NHLBI · YALE UNIVERSITY · PI Mitchel R Stacy · 2017 to 2026
$3.8M
Molecular Imaging of Atherosclerosis in Peripheral Artery DiseaseR01HL173102 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mitchel R Stacy · 2025 to 2026
$1.3M
NHLBI NIH HHS R01 HL135103NHLBI NIH HHS R01 HL173102
6 · The paper itself

Abstract

backgroundA standard imaging strategy for quantifying skeletal muscle perfusion in peripheral artery disease (PAD) does not exist, and the widespread use of PET imaging for this purpose has traditionally been limited by the need for onsite production of short half-life perfusion radioisotopes. Therefore, this study investigated the feasibility of multiparametric PET imaging with commercially available fluorine-18 (

methodsEight Yorkshire pigs underwent 60-min dynamic

resultsCalf perfusion and MRGlu were significantly reduced following peripheral artery occlusion and recovered to control levels 2 weeks later. Recovery of perfusion and metabolism in calf skeletal muscle coincided with a significant increase in calf muscle capillary density 2 weeks after arterial occlusion.

conclusionsThis study demonstrates the novel use of dynamic, multiparametric

Indexed as

Fluorodeoxyglucose F18Muscle, SkeletalPeripheral Arterial DiseasePositron-Emission TomographyAnimalsDisease Models, AnimalFemalePerfusionSwineFluorodeoxyglucose F18FluorodeoxyglucoseMetabolismPerfusion imagingPeripheral artery diseasePETSkeletal muscle

Identifiers

PMID42067735
PMCPMC13337911

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.