SynthesisBMC gastroenterology2026
Effect of human albumin infusion on inflammation, oxidative stress, and prognosis in decompensated cirrhosis: a prospective cohort study with a meta-analysis.
Synthesis in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Beyond the Tipping Point: Advances in the Diagnosis and Management of Acute-on-Chronic Liver Failure and End-Stage Liver Disease.Diagnostics (Basel, Switzerland) · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundHuman albumin (HA) infusion is beneficial for the management of decompensated cirrhosis, but its mechanism remains unclear. This study aimed to evaluate the effect of HA infusion on systemic inflammation, oxidative stress, and prognosis in decompensated cirrhosis.
methodsIn a cohort study, patients with acute decompensated cirrhosis were enrolled and categorized according to HA infusion. Serum interleukin (IL)-6, IL-10, tumor necrosis factor-alpha (TNF-α), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) levels were measured before and after treatment. We compared the one-year cumulative incidence of further decompensation between the two groups. In a meta-analysis, all relevant papers were systematically searched, and pooled using a random-effects model.
resultsIn the cohort study, 55 patients were included, of whom 23 received HA infusion. HA infusion significantly reduced IL-6 (92.79 ± 144.14 vs. 66.99 ± 89.61, P = 0.031) and MDA (15.19 ± 8.44 vs. 11.05 ± 6.77, P = 0.006) levels, but increased GSH (135.76 ± 14.91 vs. 142.00 ± 19.69, P = 0.033) level. ∆IL-6 (-25.80 ± 64.28 vs. 1.83 ± 25.05, P = 0.013) and ∆TNF-α (-12.95 ± 28.91 vs. 1.82 ± 11.31, P = 0.037) were greater in the HA group than in the control group. One-year cumulative incidence of further decompensation was significantly lower in the HA group than in the control group (P = 0.036). HA infusion was an independent protective factor of further decompensation (sHR = 0.312, P = 0.02). In the meta-analysis, 7 papers with 450 patients were included. ∆IL-6, ∆TNF-α, and ∆MDA were greater in the HA group than in the control group, but the difference was not statistically significant.
conclusionsHA infusion may reduce the risk of further decompensation by improving systemic inflammation and oxidative stress in decompensated cirrhosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.