Evidence map›Paper›PMID 42067850›Full record

ArticleBMC oral health2026

Effects of different numbers of micro-osteoperforations on acceleration of orthodontic tooth movement and alveolar bone remodeling in rats.

Yingyu Chen, Mao Liu, Fan Yang, Yi Lu, Di Jiang, Bin Wu, Bin Yan

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yingyu Chen *Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Mao Liu *Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing, China.
Fan YangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Yi LuCollege of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, China.
Di JiangCollege of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, China.
Bin WuCollege of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing, China. wubin@njfu.edu.cn.
Bin YanDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China. byan@njmu.edu.cn.

Funding

Jiangsu Funding Program for Excellent Postdoctoral Talent 2025ZB614National Natural Science Foundation of China 82371000
6 · The paper itself

Abstract

‌

backgroundMicro-osteoperforations (MOPs) have been confirmed to accelerate orthodontic tooth movement (OTM). However, the optimal number of perforations and the associated changes in alveolar bone structure, composition, and biomechanical properties under different numbers of perforations remain unclear.

methodsSeventy-two Sprague-Dawley rats undergoing OTM were divided into four groups: OTM (0 MOPs), 2MOP, 3MOP, or 4MOP. Rats were euthanized on Days 3, 7, or 14, and maxillary samples were analyzed using micro-CT, Raman spectroscopy, and nanoindentation to assess bone morphology, composition, and biomechanical properties.

resultsMOPs accelerated OTM, with 3MOP and 4MOP showing superior efficacy to 2MOP. Alveolar bone in 3MOP and 4MOP groups exhibited initial resorption followed by regeneration from Days 3-14. Mineral-to-matrix ratios decreased then increased from Days 3-14 across all groups, while carbonate substitution levels showed the opposite trend. Elastic modulus and hardness followed a similar decreasing-increasing pattern. No consistent pattern of intergroup differences was observed in bone microstructure, chemical composition, or biomechanical properties.

conclusionsMOPs can accelerate OTM, with three MOPs potentially offering a more effective balance between therapeutic efficacy and surgical intervention. No additional acceleration effect was observed in the four-perforation group. Under higher trauma levels (≥3 MOPs), alveolar bone demonstrated a time-dependent transition (initial resorption followed by regeneration) across microstructural, compositional, and biomechanical parameters.

Indexed as

Alveolar ProcessBone RemodelingTooth Movement TechniquesAnimalsBiomechanical PhenomenaElastic ModulusMaleMaxillaRatsRats, Sprague-DawleySpectrum Analysis, RamanX-Ray MicrotomographyAlveolar boneBiomechanical propertiesMicro-osteoperforationsOrthodontic tooth movement

Identifiers

PMID42067850
PMCPMC13295889

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.