Evidence map›Paper›PMID 42068034›Full record

ArticleGut microbes2026

Kelly R Kan, Marco Constante, Sara Rahmani, Gaston H Rueda, Mark Wulczynski, Maria Ines Pinto-Sanchez, Xavier Roux, Premysl Bercik, Heather J Galipeau, Alberto Caminero and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kelly R KanDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Marco ConstanteDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Sara RahmaniDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Gaston H RuedaDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Mark WulczynskiDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Maria Ines Pinto-SanchezDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-9040-9824
Xavier RouxMicrobiology Department, Biocodex, 3 Chemin d'Armancourt, Compiègne, France.
Premysl BercikDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-8707-1781
Heather J GalipeauDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Alberto CamineroDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-9555-7167
Elena F VerduDepartment of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-6346-2665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CeD) is an immune-mediated condition that leads to small intestinal villous atrophy and is driven by dietary gluten in individuals carrying HLA-DQ2 and DQ8. Microbial factors have been implicated in both the onset of CeD and persistent symptoms (non-responsive CeD) after the gluten-free diet (GFD), through mechanisms including impaired tryptophan metabolism and aryl hydrocarbon receptor (AhR) pathway activation. Although probiotics have been shown to be safe in CeD, there are currently no clinical recommendations for strains that target disease-related mechanisms. We here demonstrate that

Indexed as

Basic Helix-Loop-Helix ProteinsCeliac DiseaseGastrointestinal MicrobiomeIntestine, SmallProbioticsReceptors, Aryl HydrocarbonSaccharomyces boulardiiAnimalsDiet, Gluten-FreeDuodenumGlutensHLA-DQ AntigensHumansLimosilactobacillus reuteriMiceSignal TransductionBasic Helix-Loop-Helix ProteinsGlutensHLA-DQ8 antigenHLA-DQ AntigensReceptors, Aryl HydrocarbonTryptophanaryl hydrocarbon receptor (AhR)Celiac diseaseprobioticsprotein degradationSaccharomyces boulardiitryptophan metabolism

Identifiers

PMID42068034
PMCPMC13138080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.