Evidence mapPaperPMID 42068417Full record

ReviewCurrent atherosclerosis reports2026

Regulation of Cholesterol and Triglyceride Metabolism by Fatty acid Ethanolamides.

Sean S Davies, Reza Fadaei

Abstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sean S DaviesDepartment of Pharmacology, School of Medicine Basic Sciences, Vanderbilt University, 556B Robinson Research Building, Nashville, TN, 37232-6602, USA. Sean.davies@vanderbilt.edu.
Reza FadaeiDepartment of Pharmacology, School of Medicine Basic Sciences, Vanderbilt University, 556B Robinson Research Building, Nashville, TN, 37232-6602, USA.

Funding

the National Heart Lung and Blood Institute P01HL116263
6 · The paper itself

Abstract

purpose of reviewThis paper reviews the existing literature supporting a role for fatty acid ethanolamides including oleoylethanolamide and palmitoylethanolamide in regulating cholesterol and triglyceride metabolism and the mechanisms underlying these effects. RECENT

findingsDeletion of various fatty acid ethanolamide biosynthesis genes in cellular models and small animal models have provided additional evidence that endogenous biosynthesis of fatty acid ethanolamides regulates cholesterol and triglyceride metabolism, while new clinical trials using oleoylethanolamide and palmitoylethanolamide support their therapeutic potential to normalize lipid levels in individuals with cardiometabolic disease. Fatty acid ethanolamides are biosynthesized in the intestine, liver, and adipose tissue in response to metabolic stimuli like fasting and feeding. These fatty acid ethanolamides then act via receptors including PPARα, GPR119, and GPR55 to regulate cholesterol and triglyceride levels and promote the resolution of inflammation, thereby protecting against cardiometabolic diseases including metabolic-dysfunction associated steatotic liver disease and atherosclerotic cardiovascular disease.

Indexed as

CholesterolEndocannabinoidsEthanolaminesOleic AcidsPalmitic AcidsTriglyceridesAmidesAnimalsAtherosclerosisHumansLipid MetabolismLiverPPAR alphaAmidesCholesterolEndocannabinoidsEthanolaminesOleic AcidsoleoylethanolamidepalmidrolPalmitic AcidsPPAR alphaTriglyceridescardiometabolic diseasesmetabolic regulationN-acyl-ethanolamineN-acyl-phosphatidylethanolamineNAPE-PLDPPARα

Identifiers

PMID42068417
PMCPMC13135594

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.