Evidence map›Paper›PMID 42069002›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2026

Triple-layered core-shell microneedle patch for sustained analgesic delivery and chondroprotection in osteoarthritis.

Hoang-Phuc Pham, Cao-Sang Truong, Rimpy Diwan, Himanshu N Bhatt, Nha-Thi Luong, Qian Wu, Suman Pahal, Aseno Sakhrie, Thi Bao Tram Tran, Zhiming Li and 1 more

Abstract read
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In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hoang-Phuc PhamPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, USA.
Cao-Sang TruongDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Rimpy DiwanPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, USA.
Himanshu N BhattPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, USA.
Nha-Thi LuongDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Qian WuPathology and Laboratory Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Suman PahalPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, USA.
Aseno SakhriePolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, USA.
Thi Bao Tram TranDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Zhiming LiDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Thanh D NguyenPolymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA. Electronic address: nguyentd@uconn.edu.

Funding

Single-administration microneedles with controlled sustained release of non-opioid analgesics to treat osteoarthritis painR21AR080919 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2022 to 2023
$474k
NIAMS NIH HHS R21 AR080919
6 · The paper itself

Abstract

Osteoarthritis (OA) is a prevalent chronic condition characterized by persistent pain, necessitating sustained therapeutic interventions to manage symptoms effectively. In this study, we introduce a novel core-shell microneedle system for sustained release, termed Microneedle-based Integrated Release with Advanced Composite Layered Efficacy (MIRACLE). The design is a triple-layered microneedle (MN) patch engineered for the prolonged management of OA-associated pain. The patch consists of a 15 × 15 array within a 1 cm

Indexed as

AnalgesicsMeloxicamOsteoarthritisAdministration, CutaneousAnimalsDelayed-Action PreparationsMaleMicroneedle Drug DeliveryNeedlesRatsRats, Sprague-DawleyTransdermal PatchAnalgesicsDelayed-Action PreparationsMeloxicamMicroneedleOsteoarthritisPain managementTransdermal delivery

Identifiers

PMID42069002
PMCPMC13400157

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.