Evidence map›Paper›PMID 42069025›Full record

ArticleNeuroImage2026

Deep-learning saturation transfer magnetic resonance fingerprinting (ST-MRF) in patients with Parkinson's disease.

Jannik Prasuhn, Munendra Singh, Sultan Z Mahmud, Nirbhay N Yadav, Ted M Dawson, Kelly A Mills, Peter van Zijl, Hye-Young Heo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jannik PrasuhnF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, University-Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Center for Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.
Munendra SinghDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sultan Z MahmudDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nirbhay N YadavF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA; Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ted M DawsonDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kelly A MillsDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Peter van ZijlF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA; Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hye-Young HeoF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA; Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: hheo1@jhmi.edu.

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Chemical Exchange Saturation Transfer MR FingerprintingR01EB029974 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI HEO, HYE YOUNG · 2021 to 2024
$1.4M
NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB029974NICHD NIH HHS P50 HD103538
6 · The paper itself

Abstract

Parkinson's disease (PD) is marked by progressive neurodegeneration in the substantia nigra (SN). This study evaluated deep-learning saturation-transfer magnetic resonance fingerprinting (ST-MRF) to quantify molecular and microstructural changes in PD. We examined 23 patients with PD (PwPD) and 22 matched healthy controls (HCs) using multimodal imaging, including ST-MRF. ST-MRF detected significant molecular and microstructural alterations in the SN of PwPD compared to HCs, including increases in magnetization transfer ratio at 3.5 ppm (MTR(3.5ppm, 1.5 µT); 0.612 ± 0.022 vs. 0.597 ± 0.021, p = 0.014), MTR(-3.5ppm, 1.5 µT); 0.614 ± 0.021 vs. 0.586 ± 0.019, p = 0.008)), and decreases in T

Indexed as

Parkinson DiseaseSubstantia NigraDeep LearningFemaleHumansMagnetic Resonance ImagingMaleChemical Exchange Saturation Transfer (CEST)Magnetic resonance fingerprinting (MRF)Magnetization transfer contrast (MTC)Parkinson’s disease (PD)Substantia nigra (SN)

Identifiers

PMID42069025
PMCPMC13270658

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.