Evidence map›Paper›PMID 42070212›Full record

ArticleAngiogenesis2026

Platelet-derived growth factor receptor β F7 mutations result in and exacerbate the severity of vascular dysplasia in the brain arteriovenous malformation through enhancing angiogenesis.

Alka Yadav, Leandro Barbosa Do Prado, Mustafa Mohamed, Calvin Wang, Joshua Shi, Zahra Shabani, Rich Liang, Kelly Press, Courtney Tom, Ethan A Winkler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angiogenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alka YadavDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Leandro Barbosa Do PradoDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Mustafa MohamedDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Calvin WangDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Joshua ShiDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Zahra ShabaniDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Rich LiangDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Kelly PressDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Courtney TomDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA.
Ethan A WinklerDepartment of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Hua SuDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Aven, Box 1363, San Francisco, CA, 94110, USA. hua.su@ucsf.edu.ORCID 0000-0003-1566-9877

Funding

National Institutes of Health and Michael Ryan Zodda Foundation to H.S. NIH- R01 HL122774, NS027713 and NS112819
6 · The paper itself

Abstract

Brain arteriovenous malformations (bAVMs) are tangles of abnormal vessels that shunt blood directly from arteries to veins. The reduction of pericytes is linked to hemorrhage in bAVMs. The Pdgfb/Pdgfrβ signaling pathway is crucial for regulating pericyte recruitment during angiogenesis. Here, we show that mice with Pdgfrβ F7 mutations developed cerebrovascular dysplasia in the brain’s angiogenic region, associated with increased pro-angiogenic and inflammatory signaling. Interestingly, the expression of activin receptor-like kinase 1 (Alk1) is decreased in the brain’s angiogenic region of Pdgfrβ F7 heterozygous mice. Overexpression of ALK1 in brain endothelial cells (ECs) reduces angiogenic signaling and the severity of vascular dysplasia in Pdgfrβ F7 heterozygous mice. Pdgfrβ F7 mutations also increased dysplastic vessels and reduced pericyte coverage in the bAVM in endoglin-deficient mice. Endoglin is an AVM causative gene. Our data indicate that Pdgfrβ F7 mutations result in cerebrovascular dysplasia and worsen the bAVM phenotype in endoglin mutant mice by enhancing angiogenesis and inflammation. Overexpression of ALK1 in brain ECs reduces the severity of cerebrovascular dysplasia in Pdgfrβ F7 heterozygous mice through downregulating angiogenic signaling.

Indexed as

AngiogenesisIntracranial Arteriovenous MalformationsMutationNeovascularization, PathologicReceptor, Platelet-Derived Growth Factor betaActivin Receptors, Type IActivin Receptors, Type IIAnimalsBrainEndoglinEndothelial CellsMicePericytesSignal TransductionActivin Receptors, Type IActivin Receptors, Type IIAcvrl1 protein, mouseEndoglinEng protein, mouseReceptor, Platelet-Derived Growth Factor betaAlk1Brain arteriovenous malformationEndoglinPericytePlatelet-derived growth factor receptor-β

Identifiers

PMID42070212
PMCPMC13136212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.