CuO stabilized on magnetic decorated GO nanosheets for efficient synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione and 1,4-dihydropyridine derivatives under green conditions.

Mohammad G Dekamin, Mohammad Eslami, Elham Mahdavi

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Mohammad G DekaminPharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. mdekamin@iust.ac.ir.

Mohammad EslamiDepartment of Chemistry, Faculty of Basic Science, Behbahan Khatam Alanbia University of Technology, Behbahan, Iran.

Elham MahdaviPharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

Funding

Iran University of Science and Technology 160/25285

6 · The paper itself

Abstract

This study presents a green, efficient and sustainable method for synthesizing biologically active 3,4-dihydropyrimidine-2(1H)-one/thione (3,4-DHPMs/3,4-DHPMTs) and 1,4-dihydropyridine (1,4-DHPs) heterocycles. The protocol involves a one-pot, three-component condensation of aldehydes, 1,3-dicarbonyl compounds, and urea or ammonium carbonate, catalyzed by heterogeneous CuO stabilized on magnetic decorated GO nanosheets (CuO/mGO-TA-Me-BTA) nanocomposite. The method adheres to green chemistry principles, offering advantages such as short reaction times, high yields, easy work-up, and the use of a recyclable and low-cost catalyst. The catalyst demonstrated remarkable stability and could be reused up to six times without significant loss of its activity. The CuO/mGO-TA-Me-BTA nanocomposite was extensively characterized using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX) spectroscopy, EDX elemental mapping, thermogravimetric analysis (TGA), atomic absorption spectroscopy (AAS), and vibrating sample magnetometry (VSM).

Identifiers

PMID42071013

DOI10.1038/s41598-025-34312-9

PMCPMC13342554

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.