Evidence mapPaperPMID 42072503Full record

ReviewEntropy (Basel, Switzerland)2026

Human-in-the-Loop Artificial Intelligence: A Systematic Review of Concepts, Methods, and Applications.

Konstantinos Lazaros, Aristidis G Vrahatis, Sotiris Kotsiantis

Abstract readReview
In one paragraph

Review in Entropy (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Konstantinos LazarosDepartment of Informatics, Ionian University, 49100 Corfu, Greece.ORCID 0000-0002-9527-3946
Aristidis G VrahatisDepartment of Informatics, Ionian University, 49100 Corfu, Greece.ORCID 0000-0003-1892-0000
Sotiris KotsiantisDepartment of Mathematics, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-2247-3082

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of human judgment into artificial intelligence (AI) systems has emerged as a key research direction, particularly for high-stakes applications where full automation remains insufficient. Human-in-the-Loop (HITL) AI represents a field that combines machine learning capabilities with human oversight, feedback, and decision-making at various stages of the AI pipeline. This survey provides a systematic review of HITL approaches, covering theoretical foundations, technical methods, ethical considerations, and domain-specific applications. We propose a unified taxonomy that categorizes HITL systems based on loop placement, interaction granularity, and temporal characteristics. This review synthesizes findings from healthcare, autonomous systems, cybersecurity, and other high-risk domains where human oversight is essential. We also examine the challenges of scalability, cognitive load, and trust calibration that affect the practical deployment of HITL systems. The final section outlines open research directions and introduces a framework for designing effective human-AI collaborative systems.

Indexed as

active learningartificial intelligenceexplainable AIhuman–AI collaborationhuman-in-the-loophuman oversightmachine learningreinforcement learning

Identifiers

PMID42072503
PMCPMC13114286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.