Evidence map›Paper›PMID 42072621›Full record

ReviewBiomolecules2026

The N6-Methyladenosine RNA Demethylase AlkB Homolog 5 (ALKBH5) in Metabolic Diseases: Molecular Mechanisms and Pharmacological Implications-A Review.

Guida Cai, Leyi Fu, Xi Zhang, Meiling Yan

Abstract readReview
In one paragraph

Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guida CaiKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China Guangdong, Institute of Chinese Medicine, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Leyi FuGuangdong Provincial Engineering, Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Xi ZhangKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China Guangdong, Institute of Chinese Medicine, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Meiling YanKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China Guangdong, Institute of Chinese Medicine, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.ORCID 0000-0001-7652-129X

Funding

Guangdong Basic and Applied Basic Research Foundation of Natural Science Foundation project 2025A1515010833Guangzhou Science and Technology Bureau SL2024A04J00652National Natural Science Foundation of China 82304481
6 · The paper itself

Abstract

Metabolic diseases, including type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated fatty liver disease (MAFLD), are chronic disorders characterized by dysregulated glucose and lipid homeostasis and represent major contributors to insulin resistance, cardiovascular complications, and liver injury. Despite considerable progress in elucidating their pathogenesis, effective preventive and therapeutic strategies remain limited. N6-methyladenosine (m

Indexed as

AdenosineAlkB Homolog 5, RNA DemethylaseMetabolic DiseasesAnimalsEpitranscriptomeHumansRNA MethylationAdenosineALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseN-methyladenosineALKBH5epitranscriptomic regulationm6A RNA methylationmetabolic diseasestherapeutic potential

Identifiers

PMID42072621
PMCPMC13113226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.