ReviewBiomolecules2026
Microbial Hyaluronidases: From Obscure Virulence Factors to Promising Therapeutic Targets.
Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Detoxified Yam to Bioactive Extracts: Integrated Extraction and In Silico Evidence of Anti-Biofilm Activity ofLife (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Hyaluronan (HA) is a major extracellular matrix glycosaminoglycan essential for tissue integrity, immune homeostasis, and host defense. Many microbial pathogens exploit host HA by producing hyaluronidases (Hyls), enzymes that degrade HA to promote tissue invasion, nutrient acquisition, immune modulation, and biofilm formation. Unlike mammalian Hyls, microbial Hyls predominantly function as β-elimination lyases, generating unsaturated disaccharides and oligosaccharides with distinct biological activities. Recent mechanistic and structural insights reveal that distinct microbial Hyl variants uniquely shape host-microbe interactions and disease outcomes. This review focuses on microbial Hyls, specifically bacterial Hyls, emphasizing their roles in host immune regulation and inflammatory diseases, particularly in
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.