Discovery of p-Coumaric Acid as a Candidate Cholesterol-Lowering Factor in Germinated Brown Rice via Untargeted Metabolomics Combined with a Cholesterol-Induced HepG2 Cell Model.

Ningxin Ding, Xiangyu Pang, Yixuan Yan, Mingcong Fan, Haifeng Qian, Li Wang, Yan Li

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ningxin DingState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Xiangyu PangState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Yixuan YanState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Mingcong FanState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Haifeng QianState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Li WangState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.

Yan LiState Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.ORCID 0000-0002-9402-1093

Funding

Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University 2022-3-1Earmarked Fund for China Agriculture Research System CARS-08-G19Fundamental Research Funds for the Central University JUSRP221001Ministry of Science and Technology of China 2022YFF1100502National Natural Science Foundation of China 32071166 and 32072254"Qing Lan Project" of Jiangsu Province noneResearch Program of State Key Lab-oratory of Food Science and Resources, Jiangnan University No.SKLF-ZZB-202514Young Elite Scientists Sponsorship Program by CAST 2020QNRC001

6 · The paper itself

Abstract

Hypercholesterolemia is a major modifiable risk factor for cardiovascular disease. Although germinated brown rice (GBR) is rich in bioactive constituents and has shown preliminary lipid-regulating potential, the active compounds and underlying mechanisms remain unclear. Therefore, this study comparatively investigated extracts from four GBR cultivars and evaluated their cholesterol-regulating activity using untargeted metabolomics in combination with a cholesterol-induced HepG2 cell model. After 36 h of germination, the extracts showed significantly increased total phenolic content, total flavonoid content, and antioxidant activities (

Indexed as

cholesterol metabolismgerminated brown ricemetabolomicsp-coumaric acid

Identifiers

PMID42073232

DOI10.3390/foods15081344

PMCPMC13114526

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.