Preliminary Prediction of Potential Hepatoprotective Properties of Jujube Extract in Rats Using Metabolomics and Bioinformatics.

Mengyuan Liu, Yali Dang, Shikun Suo, Yanli Wang, Daodong Pan, Xinchang Gao

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengyuan LiuZhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.

Yali DangZhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.ORCID 0000-0001-6853-4699

Shikun SuoZhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.ORCID 0009-0002-9591-9986

Yanli WangZhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.

Daodong PanZhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China.

Xinchang GaoInstitute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.

Funding

People's Government of Zhejiang Province 2024C01248(SD2Science and Technology Department of Zhejiang Province 2025SNJF038Xinjiang Production and Construction Corps 2024AB053Yongjiang Laboratory 2024H001

6 · The paper itself

Abstract

An integrated approach combining metabolomics, network pharmacology, and molecular docking was employed to systematically explore the serum-absorbed components of jujube, their potential targets, and regulatory pathways. UPLC-MS/MS was used to characterize the absorbed components, while network pharmacology was applied to predict potential targets associated with alcoholic liver disease (ALD). A total of 10 absorbed components and 323 common targets were identified. Among the key components, quercetin, (-)-epigallocatechin, and methyl gallate exhibited strong binding affinities to eight core targets, including AKT serine/threonine kinase 1 (AKT1) and mitogen-activated protein kinase 1 (MAPK1), with quercetin showing the highest content. Jujube intervention significantly altered the serum metabolic profiles of healthy rats, with distinct differences observed between the control and jujube-treated groups. Bioinformatics analysis revealed that the differential metabolites were mainly enriched in the diterpenoid biosynthesis pathway. These findings provide a systematic and preliminary characterization of the serum-absorbed components of jujube, their potential ALD-related targets, and their regulatory effects on serum metabolism in healthy rats. This study provides a preliminary theoretical reference and direction for further research on the potential role of jujube in ALD.

Indexed as

absorbed componentsalcoholic liver diseasejujubemetabolomicsmolecular dockingnetwork pharmacology

Identifiers

PMID42073295

DOI10.3390/foods15081407

PMCPMC13114682

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.