ArticleLife (Basel, Switzerland)2026
Atypical Phenotypes of Mitochondrial Cristae Architecture in Selected Human Aging Striated Muscles-Transmission Electron Microscope Studies.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The diversity of mitochondria ultrastructure in human aging striated muscles is presented in relation to the complexity and variability of the cristae architecture and in relation to the environment of mitochondrial occurrence in the muscle fiber on the example of the orbicularis oculi. Ultrastructure analysis of mitochondria in muscles was performed using a transmission electron microscope. The studies revealed the presence of mitochondria of various sizes and unexpected shapes, and also modifications of the cristae architecture which included the occurrence of different configurations of membranes. In some mitochondria, instead of cristae, crystalline inclusion bodies and granules resembling calcium deposits were found. The range of diversity of the studied morphotypes of mitochondria exceeds the algorithms for the morphology of these organelles presented in the literature to date. This diversity of mitochondria should probably be viewed as a manifestation of evolution from the classical cristae architecture to a wide range of forms of mitochondria corresponding to the current environmental conditions of the muscle fiber.
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