ReviewLife (Basel, Switzerland)2026
Sleep Disorders and Cognitive Function in Multiple Sclerosis: A Systematic Review of Polysomnographic Studies and Implications for Neurorehabilitation Strategies.
Review in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Subjective sleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in multiple sclerosis.Journal of neurology · 2026Article
- Machine Learning-Based Prediction of Sleep Quality in Patients with Multiple Sclerosis.Medical sciences (Basel, Switzerland) · 2026Observational
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Cognitive rehabilitation represents a cornerstone of disease management in multiple sclerosis (MS), targeting the progressive cognitive decline that affects a significant proportion of patients. Despite growing evidence supporting its clinical utility, rehabilitation outcomes remain variable, and identifying modifiable factors that limit its efficacy has become a research priority. Sleep disorders are common in MS and have been increasingly linked to cognitive impairment, yet evidence based on objective polysomnographic assessment remains limited, and the specific parameters that influence cognitive function are poorly understood. This review synthesizes evidence from polysomnographic studies examining how sleep disturbances influence cognitive performance in MS patients. Following a systematic search of PubMed, EMBASE, and the Cochrane Library, 488 patients were included. Sleep fragmentation, reduced sleep efficiency, and oxygen desaturation indices were associated with impairments in attention, information processing speed, and verbal memory, with nocturnal hypoxia emerging as a potentially important mechanism of cognitive impairment. These findings suggest that identifying and treating sleep disorders may be essential for optimizing cognitive rehabilitation outcomes in MS. Further longitudinal studies are needed to determine whether addressing sleep pathology can enhance rehabilitation efficacy and preserve cognitive function over time.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.